MF-CTCL is a rare,
difficult-to-diagnose condition1,2
Overview of early stage MF-CTCL
Can mimic >50 varieties of skin diseases3
Often mistaken for eczema, psoriasis, or non-specific dermatitis1
Symptoms tend to appear on non-sun-exposed areas of the body4
- Itchy, flaky red patches on the skin5
- Patches can be painful and occasionally bleed5
Patches, plaques, hypopigmentation, itching
Typically produced by neoplastic T-cells localizing to the skin6
Risk of disease progression7
13% to 32% with early MF-CTCL7
Most commonly affects
black males, age 55 to 60 years8
A symptomatic, yet indolent malignancy7
MF-CTCL is the most common CTCL subtype (~50% of CTCL cases)8
References:
- Cutaneous Lymphoma Foundation. CTCL-MF fast facts. Cutaneous Lymphoma Foundation website. https://www.clfoundation.org/sites/default/files/2017-08/cl_fast_facts.pdf. Accessed November 30, 2018.
- Chuang TY, Su WP, Muller SA. Incidence of cutaneous T cell lymphoma and other rare skin cancers in a defined population. J Am Acad Dermatol. 1990;23:254-256.
- Nashan D, Faulhaber D, Stander S, Luger TA, Stadler R. Mycosis fungoides: a dermatological masquerader. Br J Derm. 2007;156(1):1-10.
- Song SX, Willemze R, Swerdlow SH, Kinney MC, Said JW. Mycosis fungoides: report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop. Am J Clin Pathol. 2013;139(4):466-490.
- Ahn CS, ALSayyah A, Sangüeza OP. Mycosis fungoides: an updated review of clinicopathologic variants. Am J Dermatopathol. 2014;36(12):933-951.
- Kim YH, Liu HL, Mraz-Gernhard S, Varghese A, Hoppe RT. Long-term outcome of 525 patients with mycosis fungoides and Sézary syndrome. Clinical prognostic factors and risk for disease progression. Arch Dermatol. 2003;139:857-866.
- Kim EJ, Hess S, Richardson SK, Newton S, et al. Immunopathogenesis and therapy of cutaneous T cell lymphoma. J Clin Invest. 2005;115(4):798-812.
- Ahn CS, ALSayyah A, Sangüeza OP. Mycosis fungoides: an updated review of clinicopathologic variants. Am J Dermatopathol. 2014;36(12):933-951.